'hyperperfusion' originates from modern English, formed from the Greek prefix 'hyper-' and the noun 'perfusion' (from Latin 'perfundere'), where 'hyper-' meant 'over' and 'perfundere' meant 'to pour through'.

'perfusion' changed from Latin word 'perfundere' (to pour through) to Late Latin 'perfusio' and then into Medieval/Modern usage as 'perfusion'; 'hyper-' derives from Greek 'huper' and entered English as the combining form 'hyper-', which was attached to 'perfusion' in modern medical English to create 'hyperperfusion'.

Initially the components conveyed the literal idea of 'over' + 'pouring through'; over time the compound's use became specialized in medicine to mean 'abnormally increased blood flow to a tissue or organ'.